O Pedersen Selected Research

Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)

11/2007	Partial and whole gene deletion mutations of the GCK and HNF1A genes in maturity-onset diabetes of the young.
1/2006	IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?
5/2005	Molecular genetics and phenotypic characteristics of MODY caused by hepatocyte nuclear factor 4alpha mutations in a large European collection.
4/2005	Preserved insulin response to tolbutamide in hepatocyte nuclear factor-1alpha mutation carriers.
10/2003	The pathophysiology of diabetes involves a defective amplification of the late-phase insulin response to glucose by glucose-dependent insulinotropic polypeptide-regardless of etiology and phenotype.
2/2003	Genetic epidemiology of MODY in the Czech republic: new mutations in the MODY genes HNF-4alpha, GCK and HNF-1alpha.
3/2002	The genetic abnormality in the beta cell determines the response to an oral glucose load.
3/2000	Missense mutations in the human insulin promoter factor-1 gene and their relation to maturity-onset diabetes of the young and late-onset type 2 diabetes mellitus in caucasians.

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O Pedersen Research Topics

Disease

60	Type 2 Diabetes Mellitus (MODY) 08/2014 - 03/2000
37	Insulin Resistance 12/2016 - 02/2000
20	Obesity 12/2016 - 09/2000
10	Birth Weight (Birth Weights) 12/2010 - 04/2000
7	Body Weight (Weight, Body) 05/2015 - 07/2001
7	Diabetes Mellitus 01/2011 - 08/2001
7	Glucose Intolerance 03/2010 - 04/2000
5	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 07/2008 - 07/2001
5	Mason-Type Diabetes 10/2003 - 03/2000
4	Inflammation (Inflammations) 06/2015 - 05/2005
4	Weight Gain 05/2015 - 09/2000
4	Cardiovascular Diseases (Cardiovascular Disease) 04/2009 - 10/2001
4	Myocardial Infarction 04/2009 - 10/2001
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2018 - 02/2005
3	Hypersensitivity (Allergy) 01/2018 - 04/2005
3	Stroke (Strokes) 04/2009 - 10/2001
3	Diabetic Nephropathies (Diabetic Nephropathy) 07/2008 - 08/2001
2	Asthma (Bronchial Asthma) 01/2018 - 01/2010
2	Weight Loss (Weight Reduction) 05/2015 - 03/2006
2	Chronic Kidney Failure (Chronic Renal Failure) 07/2008 - 09/2001
2	Hypertension (High Blood Pressure) 04/2007 - 03/2007
2	Overweight 02/2007 - 09/2006
2	Type 2 Maturity-Onset Diabetes of the Young 07/2006 - 02/2003
2	Type 3 Maturity-Onset Diabetes of the Young 04/2005 - 02/2003
2	Type 1 Maturity-Onset Diabetes of the Young 02/2003 - 03/2000
2	Sickle Cell Anemia (Hemoglobin S Disease) 03/2001 - 03/2000
1	Psoriasis (Pustulosis Palmaris et Plantaris) 01/2022
1	Seasonal Allergic Rhinitis (Hay Fever) 01/2018
1	Dyslipidemias (Dyslipidemia) 12/2016
1	Pediatric Obesity 12/2016
1	Genetic Risk Score 01/2016
1	Bone Resorption 04/2014
1	Flushing 01/2010
1	Insulinoma 09/2009

Drug/Important Bio-Agent (IBA)

43	Glucose (Dextrose)FDA LinkGeneric 05/2015 - 04/2000
42	Insulin (Novolin)FDA Link 02/2013 - 03/2000
8	Transcription Factors (Transcription Factor)IBA 01/2013 - 03/2000
8	Hepatocyte Nuclear Factor 1-alpha (Hepatocyte Nuclear Factor 1 alpha)IBA 11/2007 - 03/2000
7	LipidsIBA 12/2016 - 04/2000
5	Hormones (Hormone)IBA 05/2015 - 05/2008
4	GlucokinaseIBA 11/2011 - 03/2002
4	Hepatocyte Nuclear FactorsIBA 01/2011 - 03/2005
4	C-PeptideIBA 05/2007 - 04/2000
4	NucleotidesIBA 02/2007 - 03/2000
3	Biomarkers (Surrogate Marker)IBA 01/2018 - 11/2002
3	LeptinIBA 05/2015 - 07/2001
3	Peptides (Polypeptides)IBA 04/2014 - 06/2005
3	Glucagon-Like Peptide 1 (GLP 1)IBA 01/2013 - 10/2003
3	IncretinsIBA 01/2011 - 05/2008
3	Metformin (Glucophage)FDA LinkGeneric 04/2009 - 11/2001
3	CytokinesIBA 03/2009 - 07/2004
3	PPAR gammaIBA 07/2008 - 01/2006
3	Triglycerides (Triacylglycerol)IBA 01/2008 - 10/2001
3	Amino Acids FDA Link 03/2007 - 12/2001
2	HDL CholesterolIBA 02/2013 - 10/2001
2	Glucagon (Glukagon)FDA Link 01/2013 - 11/2011
2	Interleukin-6 (Interleukin 6)IBA 03/2010 - 02/2005
2	Codon (Codons)IBA 09/2006 - 09/2001
2	AdiponectinIBA 05/2006 - 06/2005
2	Tolbutamide (Orinase)FDA LinkGeneric 04/2005 - 09/2000
2	Mitochondrial Uncoupling ProteinsIBA 01/2005 - 08/2001
2	Hepatocyte Nuclear Factor 1-betaIBA 10/2001 - 03/2000
2	Facilitative Glucose Transport Proteins (Glucose Transporter)IBA 08/2001 - 05/2001
1	Adalimumab (Humira)FDA Link 01/2022
1	CarbonIBA 01/2018
1	Immunoglobulin E (IgE)IBA 01/2018
1	HomocysteineIBA 01/2018
1	SugarsIBA 12/2016
1	Folic Acid (Vitamin M)FDA LinkGeneric 01/2016
1	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2016
1	DNA (Deoxyribonucleic Acid)IBA 06/2015
1	Glucagon-Like Peptide-1 ReceptorIBA 05/2015
1	Liraglutide FDA Link 05/2015
1	Leptin ReceptorsIBA 05/2015
1	Dopamine Receptors (Dopamine Receptor)IBA 08/2014
1	Hepatocyte Nuclear Factor 4IBA 11/2011
1	Glucagon-Like Peptides (Enteroglucagon)IBA 11/2011
1	OxyntomodulinIBA 11/2011
1	antineoplaston A10 (A 10)IBA 09/2011
1	P-2 (P 2)IBA 04/2011
1	Lamin Type A (Lamin A)IBA 08/2010
1	Messenger RNA (mRNA)IBA 08/2010
1	salicylhydroxamic acid (SHAM)IBA 03/2010
1	AutoantibodiesIBA 03/2010
1	AcetaldehydeIBA 01/2010
1	Type 4 Melanocortin Receptor (Melanocortin-4 Receptor)IBA 01/2010
1	Oxidoreductases (Dehydrogenase)IBA 01/2010
1	aldehyde dehydrogenase (NAD(P)+) (acetaldehyde dehydrogenase)IBA 01/2010
1	Histamine (Histamine Dihydrochloride)FDA Link 01/2010
1	Ethanol (Ethyl Alcohol)IBA 01/2010
1	polyglutamineIBA 09/2009
1	alanylalanine (Ala-Ala)IBA 07/2008
1	A 19IBA 05/2008
1	Proteins (Proteins, Gene)FDA Link 05/2008
1	zinc-binding protein (zinc binding protein)IBA 05/2008
1	NFI Transcription FactorsIBA 11/2007
1	Protein Glutamine gamma Glutamyltransferase 2IBA 11/2007

Therapy/Procedure

3	Therapeutics 05/2015 - 10/2001
3	Surgical Amputation (Amputations) 04/2009 - 10/2001
1	Caloric Restriction 05/2015